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8 years ago we made a knockout mouse unraveling the function of a calcium-binding protein (Calsequestrin) in the heart muscle. Finally it is published!

Several genetically modified mice models were studied so far to investigate the role of cardiac calsequestrin (CSQ2) for the contractile function of the ventricle and for the occurrence of ventricular tachycardia. By using a CSQ2 knockout mouse we wanted to study also the atrial function of CSQ2.
Methods
These data suggest a functional role of CSQ2 not only in the ventricle but also in the atrium of mammalian hearts. Loss of CSQ2 function can cause not only arrhythmias, but also cardiac hypertrophy and heart failure.

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Link to the publication: http://onlinelibrary.wiley.com/doi/10.1111/apha.12766/full

A new study published in Nature communications with PolyGene mice suggests it all starts in the liver and not in the brain.