Publications

Scientific research papers published by clients utilising PolyGene mice.


2017
2016
2015 and older

The Lrp4R1170Q Homozygous Knock-In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans
E. Boudin, T. Yorgan, I. Fijalkowski, S. Sonntag, E. Steenackers, G. Hendrickx, S. Peeters, A. De Maré, B. Vervaet, A. Verhulst, G. Mortier, P. D’Haese, T. Schinke, W. Van Hul
J Bone Miner Res. 2017 Aug;32(8):1739-1749. doi: 10.1002/jbmr.3160

The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling
T Girardi, S Vereecke, S O Sulima, Y Khan, L Fancello, J W Briggs, C Schwab, J O de Beeck, J Verbeeck, J Royaert, E Geerdens, C Vicente, S Bornschein, C J Harrison, J P Meijerink, J Cools, J D Dinman, K R Kampen, K De Keersmaecker
Leukemia accepted article preview 24 July 2017; doi: 10.1038/leu.2017.225

Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant
Christos Tzimas, Daniel M. Johnson, Demetrio J. Santiago, Elizabeth Vafiadaki, Demetrios A. Arvanitis, Constantinos H. Davos, Aimilia Varela, Nikolaos C. Athanasiadis, Constantinos Dimitriou, Michalis Katsimpoulas, Stephan Sonntag, Mariya Kryzhanovska, Doron Shmerling, Stephan E. Lehnart, Karin R. Sipido, Evangelia G. Kranias, Despina Sanoudou
Cardiovasc Res 2017 cvx113. doi: 10.1093/cvr/cvx113

The Lrp4 R1170Q homozygous knock-in mouse recapitulates the bone phenotype of sclerosteosis in humans.
Boudin, E., Yorgan, T., Fijalkowski, I., Sonntag, S., Steenackers, E., Hendrickx, G., Peeters, S., Maré, A. D., Vervaet, B., Verhulst, A., Mortier, G., D’Haese, P., Schinke, T. and Hul, W. V.
J Bone Miner Res. Accepted Author Manuscript. doi:10.1002/jbmr.3160

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss
Martin H. Schludi, Lore Becker, Lillian Garrett, Tania F. Gendron, Qihui Zhou, Franziska Schreiber, Bastian Popper, Leda Dimou, Tim M. Strom, Juliane Winkelmann, Anne von Thaden, Kristin Rentzsch, Stephanie May, Meike Michaelsen, Benjamin M. Schwenk, Jing Tan, Benedikt Schoser, Marianne Dieterich, Leonard Petrucelli, Sabine M. Hölter, Wolfgang Wurst, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Thomas Klopstock, Thomas Arzberger, Dieter Edbauer
Acta Neuropathologica (2017). doi:10.1007/s00401-017-1711-0

Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells
Marc Riemanna, Nico Andreasa, Maria Fedoseeva, Elke Meier, Debra Weih, Helga Freytag, Ruth Schmidt-Ullrich, Ulf Klein, Zhao-Qi Wang, Falk Weih
Journal of Autoimmmunity. Available online 3 April 2017. doi:10.1016/j.jaut.2017.03.007

AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis
Randa Abdel Malik, Nina Zippel, Timo Frömel, Juliana Heidler, Sven Zukunft, Barbara Walzog, Nariman Ansari, Francesco Pampaloni, Susanne Wingert, Michael A Rieger, Ilka Wittig, Beate Fisslthaler, Ingrid Fleming
Circulation Research 2017 Jan 6; 120(1): 99–109. Published online 2017 Jan 5. doi:10.1161/CIRCRESAHA.116.309937

Novel Mouse Models of Methylmalonic Aciduria Recapitulate Phenotypic Traits with a Genetic Dosage Effect
Patrick Forny, Anke Schumann, Merima Mustedanagic, Déborah Mathis, Marie-Angela Wulf, Nadine Nägele, Claus-Dieter Langhans, Assem Zhakupova, Joerg Heeren, Ludger Scheja, Ralph Fingerhut, Heidi L. Peters, Thorsten Hornemann, Beat Thony, Stefan Kölker, Patricie Burda, D. Sean Froese, Olivier Devuyst, and Matthias R. Baumgartner
The Journal of Biological Chemistry 291, 20563-20573. 6, doi:10.1074/jbc.M116.747717, September 23, 2016

Evidence for a functional role of calsequestrin 2 in mouse atrium
Ulrich Gergs, Carola M. Fahrion, Patricia Bock, Marco Fischer, Hartmut Wache, Steffen Hauptmann, Wilhelm Schmitz and Joachim Neumann
Acta Physiologica, doi:10.1111/apha.12766

Liver-derived ketone bodies are necessary for food anticipation
Rohit Chavan, Céline Feillet, Sara S. Fonseca Costa, James E. Delorme, Takashi Okabe, Jürgen A. Ripperger, Urs Albrecht
Nature Communications 7, Article number: 10580 doi:10.1038/ncomms10580

Modulation of anxiety and fear via distinct intrahippocampal circuits
Elif Engin, Kiersten S Smith, Yudong Gao, David Nagy, Rachel A Foster, Evgeny Tsvetkov, Ruth Keist, Florence Crestani, Jean-Marc Fritschy, Vadim Y Bolshakov, Mihaly Hajos, Scott A Heldt, Uwe Rudolph
eLife 2016;5:e14120 doi:10.7554/eLife.14120

Symptomatic Improvement in Human Papillomavirus-Induced Epithelial Neoplasia by Specific Targeting of the CXCR4 Chemokine Receptor
Floriane Meuris, Françoise Gaudin, Marie-Laure Aknin, Patrice Hémon, Dominique Berrebi, Françoise Bachelerie
Journal of Investigative Dermatology, Volume 136, Issue 2, February 2016, Page 349, doi: 10.1016/j.jid.2015.11.004


A New Mouse Model of Limb-Girdle Muscular Dystrophy Type 2I Homozygous for the Common L276I Mutation Mimicking the Mild Phenotype in Humans
Krag, Thomas O. PhD; Vissing, John MD, DMSc
Journal of Neuropathology & Experimental Neurology: December 2015 – Volume 74 – Issue 12 – p 1137–1146

No Dopamine Cell Loss or Changes in Cytoskeleton Function in Transgenic Mice Expressing Physiological Levels of Wild Type or G2019S Mutant LRRK2 and in Human Fibroblasts
Marta Garcia-Miralles, Janaky Coomaraswamy, Karina Häbig, Martin C. Herzig, Natalja Funk, Frank Gillardon, Martina Maisel, Mathias Jucker, Thomas Gasser, Dagmar Galter and Saskia Biskup
PLoS One. 2015; 10(4): e0118947.

Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism
Barbara Witek, Abeer El Wakil, Christoffer Nord, Ulf Ahlgren, Maria Eriksson, Emma Vernersson-Lindahl, Åslaug Helland, Oleg A. Alexeyev, Bengt Hallberg, Ruth H. Palmer
PLoS ONE 10(5): e0123542. doi:10.1371/journal.pone.0123542

GPR17 expressing NG2-Glia: Oligodendrocyte progenitors serving as a reserve pool after injury
Francesca Viganò, Sarah Schneider, Mauro Cimino, Elisabetta Bonfanti, Paolo Gelosa, Luigi Sironi, Maria P. Abbracchio and Leda Dimou
Glia. doi: 10.1002/glia.22929

Modulation of mitochondrial morphology through mFis1 splice variants in basal conditions and starving cells
Sebastian Zamorano Villablanca
Thèse de doctorat : Univ. Genève, 2015 – Sc. 4825 – 2015/09/14

Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool
Michiel van Wyk, Justyna Pielecka-Fortuna, Siegrid Löwel, Sonja Kleinlogel
Plos Biology, (8 May 2015) | doi: 10.1371/journal.pbio.1002143

No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse
Frederic Preitner, Anabela Pimentel, Salima Metref, Corinne Berthonneche, Alexandre Sarre, Catherine Moret, Samuel Rotman, Gabriel Centeno, Dmitri Firsov and Bernard Thorens
Kidney International, (7 January 2015) | doi:10.1038/ki.2014.385

Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current
Ludovic Gillet Jean-Sébastien Rougier, Diana Shy, Stephan Sonntag, Nathalie Mougenot, Maria Essers, Doron Shmerling, Elise Balse, Stéphane N. Hatem, Hugues Abriel
Hearth Rhythm Society, January 2015, Volume 12, Issue 1, Pages 181–192

Identification of Candidate Long Noncoding RNAs Associated with Left Ventricular Hypertrophy
Zhang, L., Hamad, E. A., Vausort, M., Funakoshi, H., Feldman, A. M., Wagner, D. R. and Devaux, Y.
Clinical and Translational Science, 8: 100–106. doi: 10.1111/cts.12234

Constitutive ablation of Synapse-Associated Protein SAP97 in the mouse heart leads to decreased potassium currents and increased action potential Duration
L. Gillet, J. Rougier, S. Sonntag, D. Shy, M. Essers, D. Shmerling, H. Abriel
Proceedings of The Physiological Society

I?B kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases
Abduelhakem Ben-Addi, Agnes Mambole-Dema, Christine Brender, Stephen R. Martin, Julia Janzen, Sven Kjaer, Stephen J. Smerdon, and Steven C. Ley
Proceedings of the National Academy of Sciences of the United States of America

Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase
Srividya Sriskantharajah, Eva Gückel, Niki Tsakiri, Katrin Kierdorf, Christine Brender, Abduelhakem Ben-Addi, Marc Veldhoen, Philip N. Tsichlis, Brigitta Stockinger, Anne O’Garra, Marco Prinz, George Kollias, and Steven C. Ley
The Journal of Immunology

HMGA1 pseudogenes as candidate proto-oncogenic competitive endogenous RNAs
Francesco Esposito, Marco De Martino, Maria Grazia Petti, Floriana Forzati, Mara Tornincasa, Antonella Federico, Claudio Arra, Giovanna Maria Pierantoni, Alfredo Fusco
Oncotarget

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer
Nina Schönhuber, Barbara Seidler, Kathleen Schuck, Christian Veltkamp, Christina Schachtler, Magdalena Zukowska, Stefan Eser, Thorsten B Feyerabend, Mariel C Paul, Philipp Eser, Sabine Klein, Andrew M Lowy, Ruby Banerjee, Fangtang Yang, Chang-Lung Lee, Everett J Moding, David G Kirsch, Angelika Scheideler, Dario R Alessi, Ignacio Varela, Allan Bradley, Alexander Kind, Angelika E Schnieke, Hans-Reimer Rodewald, Roland Rad, Roland M Schmid, Günter Schneider & Dieter Saur
Nature Medicine

A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD
Pawel M. Switonski, Wojciech J. Szlachcic, Wlodzimierz J. Krzyzosiak, Maciej Figiel
Neurobiology of Disease

Genetic Deletion of SEPT7 Reveals a Cell Type-Specific Role of Septins in Microtubule Destabilization for the Completion of Cytokinesis
Manoj B. Menon, Akihiro Sawada, Anuhar Chaturvedi, Pooja Mishra, Karin Schuster-Gossler, Melanie Galla, Axel Schambach, Achim Gossler, Reinhold Förster, Michael Heuser, Alexey Kotlyarov, Makoto Kinoshita, Matthias Gaestel
PLOS Genetics

Soluble Protein CD5 or CD6 for the Treatment of Cancer or Tumor or for use as an adjuvant
Lozano Soto Francisco, Martinez Vanessa Gabriela, Fenutria Aumesquet Rafael
United States Patent Application

0150: PDZ domain proteins interacting with Nav1.5 differentially regulate Nav1.5 channel pools in mouse cardiomyocytes
Gillet L, Shy D, Sonntag S, Rougier J-S, Verkerk A, Essers M, Marsman R, Shmerling D, Bezzina C, Remme CA, and Abriel H
Arch Cardiovasc Disease 6(1): 40-41

Alternatively Spliced Tissue Factor Is Not Sufficient for Embryonic Development
Sluka SHM, Akhmedov A, Vogel J, Unruh D, Bogdanov VY, Camici GG, Lüscher TF, Ruf W, and Tanner FC
PLoS ONE 9(5): e97793. doi:10.1371/journal.pone.0097793

The Serine/Threonine Kinase Ndr2 Controls Integrin Trafficking and Integrin-Dependent Neurite Growth
Rehberg K, Kliche S, Madencioglu DA, Thiere M, Müller B, Meineke BM, Freund C, Budinger E, and Stork O
The Journal of Neuroscience, 9 April 2014, 34(15): 5342-5354

Regulation of Experimental Autoimmune Encephalomyelitis by TPL-2 Kinase
Sriskantharajah S, Gückel E, Tsakiri N, Kierdorf K, Brender C, Ben-Addi A, Veldhoen M, Tsichlis PN, Stockinger B, O’Garra A, Prinz M, Kollias G and Ley SC
J Immunol. 2014 Apr 15;192(8):3518-29

S151A d-sarcoglycan mutation causes a mild phenotype of cardiomyopathy in mice
Rutschow D, Bauer R, Göhringer C, Bekeredjian R, Schinkel S, Straub V, Koenen M, Weichenhan D, Katus HA, and Müller OJ
European Journal of Human Genetics 22, 119–125

Cell-Specific Cre Recombinase Expression Allows Selective Ablation of Glutamate Receptors from Mouse Horizontal Cells
Ströh S, Sonntag S, Janssen-Bienhold U, Schultz K, Cimiotti K, Weiler R, Willecke K and Dedek K
PLoS One. 2013 Dec 12;8(12):e83076

Cis-regulatory underpinnings of human GLI3 expression in embryonic craniofacial structures and internal organs
Abbasi AA, Minhas R, Schmidt A, Koch S, and Grzeschik KH
Dev Growth Differ. 2013 Oct;55(8):699-709

Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in ß-cells
Deisl C, Simonin A, Anderegg M, Albano G, Kovacs G, Ackermann D, Moch H, Dolci W, Thorens B, Hediger MA, and Fuster DG
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):10004-9

Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity
Klein S, Seidler B, Kettenberger A, Sibaev A, Rohn M, Feil R, Allescher HD, Vanderwinden JM, Hofmann F, Schemann M, Rad R, Storr MA, Schmid RM, Schneider G, and Saur D
Nature Communications 4:1630 doi:10.1038/ncomms2626

Establishing an in vivo p48ZnF bioluminescence mouse brain imaging model
Heese K
Neuroscience Letters, In Press, Accepted Manuscript, Available online 5 March 2013

M tuberculosis in the Adjuvant Modulates Time of Appearance of CNS-Specific Effector T Cells in the Spleen through a Polymorphic Site of TLR2
Nicolò C, Di Sante G, Procoli A, Migliara G, Piermattei A, Valentini M, Delogu G, Cittadini A, Constantin G, and Ria F
PLoS ONE 8(2): e55819. doi:10.1371/journal.pone.0055819

I?B Kinase 2 Regulates TPL-2 Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Direct Phosphorylation of TPL-2 Serine 400
Karine Roget, Abduelhakem Ben-Addi, Agnes Mambole-Dema, Thorsten Gantke, Huei-Ting Yang, Julia Janzen, Nick Morrice, Derek Abbott and Steven C. Ley
Molecular and Cellular Biology, American Society for Microbiology

Ablation of Retinal Horizontal Cells from Adult Mice Leads to Rod Degeneration and Remodeling in the Outer Retina
Sonntag S, Dedek K, Dorgau B, Schultz K, Schmidt KF, Cimiotti K, Weiler R, Löwel S, Willecke K, and Janssen-Bienhold U
J Neurosci. 2012 Aug 1;32(31):10713-24

Neuronal overexpression of IP3 receptor 2 is detrimental in mutant SOD1 mice
Staats KA, Bogaert E, Hersmus N, Jaspers T, Luyten T, Bultynck G, Parys JB, Hisatsune C, Mikoshiba K, Van Damme P, Robberecht W, Van Den Bosch L
Biochemical and Biophysical Research Communications, 429:3–4, 14 December 2012, Pages 210–213

Generation of a novel mouse model for the inducible depletion of macrophages in vivo
Gheryani N, Coffelt SB, Gartland A, Rumney RM, Kiss-Toth E, Lewis CE, Tozer GM, Greaves DR, Dear TN, Miller G
Genesis, 2012 Aug 28. doi: 10.1002/dvg.22343

Cardioprotection of Controlled and Cardiac-Specific Over-Expression of A2A-Adenosine Receptor in the Pressure Overload
Hamad EA, Zhu W, Chan TO, Myers V, Gao E, Li X, Zhang J, Song J, Zhang XQ, Cheung JY, Koch W, Feldman AM
PLoS ONE 7(7): e39919. doi:10.1371/journal.pone.0039919

A mouse line to inducibly trace the neural crest and oligodendrocyte lineage.
Simon C, Lickert H, Götz M, Dimou L.
Genesis. 2012 20 FEB 2012, DOI: 10.1002/dvg.22003

Probing transcription-specific outputs of beta-catenin in vivo.
Valenta T, Gay M, Steiner S, Draganova K, Zemke M, Hoffmans R, Cinelli P, Aguet M, Sommer L, Basler K.
Genes Dev. 2011 Dec 15;25(24):2631-43

Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells
Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM
J Physiol. 2011 Oct 15;589(Pt 20):4959-80. doi: 10.1113/jphysiol.2011.216028. Epub 2011 Aug 8

A key role for NOX4 in epithelial cell death during development of lung fibrosis.
Carnesecchi S, Deffert C, Donati Y, Basset O, Hinz B, Preynat-Seauve O, Guichard C, Arbiser JL, Banfi B, Pache JC, Barazzone-Argiroffo C, Krause KH.
Antioxid Redox Signal. 2011 Aug 1;15(3):607-19

Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis.
Duveau V, Laustela S, Barth L, Gianolini F, Vogt KE, Keist R, Chandra D, Homanics GE, Rudolph U, Fritschy JM.
Eur J Neurosci. 2011 Aug;34(3):362-73

Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control.
Witschi R, Punnakkal P, Paul J, Walczak JS, Cervero F, Fritschy JM, Kuner R, Keist R, Rudolph U, Zeilhofer HU.
J Neurosci. 2011 Jun 1;31(22):8134-42

CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice.
Nguyen HT, Dalmasso G, Torkvist L, Halfvarson J, Yan Y, Laroui H, Shmerling D, Tallone T, D’Amato M, Sitaraman SV, Merlin D.
J Clin Invest. 2011 May;121(5):1733-47

Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity.
D’Adamo MC, Shang L, Imbrici P, Brown SD, Pessia M, Tucker SJ.
J Biol Chem. 2011 Jan 7;286(1):192-8

Rolle der cAMP-Zielsequenzen in der Regulation des humanen Reningens in vitro und in vivo
Michael Desch
Doctoral Thesis, Naturwissenschaftliche Fakultät III –Biologie und vorklinische Medizin der Universität Regensburg

The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice
Schütz M, Scimemi P, Majumder P, De Siati RD, Crispino G, Rodriguez L, Bortolozzi M, Santarelli R, Seydel A, Sonntag S, Ingham N, Steel KP, Willecke K, Mammano F
Hum Mol Genet. 2010 December 15; 19(24): 4759–4773.

PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice.
Rad R, Rad L, Wang W, Cadinanos J, Vassiliou G, Rice S, Campos LS, Yusa K, Banerjee R, Li MA, de la Rosa J, Strong A, Lu D, Ellis P, Conte N, Yang FT, Liu P, Bradley A.
Science. 2010 Nov 19;330(6007):1104-7

Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells
Tykocinski LO, Sinemus A, Rezavandy E, Weiland Y, Baddeley D, Cremer C, Sonntag S, Willecke K, Derbinski J, Kyewski B.
Proc Natl Acad Sci U S A. 2010 November 9; 107(45): 19426–19431

Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons.
Mounien L, Marty N, Tarussio D, Metref S, Genoux D, Preitner F, Foretz M, Thorens B.
FASEB J. 2010 Jun;24(6):1747-58

Human intronic enhancers control distinct sub-domains of Gli3 expression during mouse CNS and limb development.
Abbasi, A. A., Paparidis, Z., Malik, S., Bangs, F., Schmidt, A., Koch,
S., Lopez-Rios, J., Grzeschik, K. H.
Developmental Biology, 2010, 10:44

Lin9, a Subunit of the Mammalian DREAMComplex, Is Essential for Embryonic Development, for Survival of Adult Mice, and for Tumor Suppression
Reichert N, Wurster S, Ulrich T, Schmitt K, Hauser S, Probst L, Götz R, Ceteci F, Moll R, Rapp U, and Gaubatz S.
Mol. Cell. Biol. 2010, 30(12):2896

Characterization of a mouse model transgenic for the Parkinson associated protein LRRK2
Trefil Martina
Diploma Thesis, Universität Wien, Zentrum für Molekulare Biologie

Mouse lens connexin23 (Gje1) does not form functional gap junction channels but causes enhanced ATP release from HeLa cells
Sonntag S, Söhl G, Dobrowolski R, Zhang J, Theis M, Winterhager E, Bukauskas FF, Willecke K.
Eur J Cell Biol. 2009 February; 88(2): 65–77

Gating, permselectivity and pH-dependent modulation of channels formed by connexin57, a major connexin of horizontal cells in the mouse retina
Palacios-Prado N, Sonntag S, Skeberdis VA, Willecke K, Bukauskas FF.
J Physiol. 2009 July 1; 587(Pt 13): 3251–3269

Connexin57 is expressed in dendro-dendritic and axo-axonal gap junctions of mouse horizontal cells and its distribution is modulated by light.
Janssen-Bienhold U, Trümpler J, Hilgen G, Schultz K, Müller LP, Sonntag S, Dedek K, Dirks P, Willecke K, Weiler R.
J Comp Neurol. 2009 Apr 1;513(4):363-74

The role of Lin9 in mouse development
Nina Reichert
Doctoral Thesis, Bayerischen Julius-Maximilians-Universität Würzburg

Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK.
Langmesser S, Tallone T, Bordon A, Rusconi S, Albrecht U.
Mol Biol. 2008 Apr 22;9:41

Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells.
Martin D, Allagnat F, Chaffard G, Caille D, Fukuda M, Regazzi R, Sbderrahmani A, Waeber G, Meda P, Maechler P, and Haefliger JA.
Diabetologia 51:1429-1439

Novel vectors for homologous recombination strategies in 3 mouse embryonic stem cells: An ES cell line expressing 4 EGFP under control of the 5T4 promoter.
Perez-Campo, F.M., Spencer, H.L., Elder, R.H., Stern, P.L. and Ward, C.M.
Exp. Cell Res. 2007, 313, 3604-3615

Cystatin C modulates cerebral beta-amyloidosis.
Kaeser SA, Herzig MC, Coomaraswamy J, Kilger E, Selenica ML, Winkler DT, Staufenbiel M, Levy E, Grubb A, Jucker M.
Nat Genet. 2007 39(12):1437-9

Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice.
Baschuk N, Utermöhlen O, Gugel R, Warnecke G, Karow U, Paulsen D, Brombacher F, Krönke M, Deppert W.
Cancer Immunol Immunother. 2007 Oct;56(10):1625-36

Homer1a is a core brain molecular correlate of sleep loss.
Maret S, Dorsaz S, Gurcel L, Pradervand S, Petit B, Pfister C, Hagenbuchle O, O’Hara BF, Franken P, Tafti M.
Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20090-5.

Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function.
Funakoshi H, Chan TO, Good JC, Libonati JR, Piuhola J, Chen X, MacDonnell SM, Lee LL, Herrmann DE, Zhang J, Martini J, Palmer TM, Sanbe A, Robbins J, Houser SR, Koch WJ, Feldman AM.
Circulation. 2006 Nov 21;114(21):2240-5

Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25
Clapp TR, Medler KF, Damak S, Margolskee RF, and Kinnamon, SC
BMC Biol. 2006; 4: 7, 10.1186/1741-7007-4-7

Strong and ubiquitous expression of transgenes targeted into the beta-actin locus by Cre/lox cassette replacement.
Shmerling D, Danzer CP, Mao X, Boisclair J, Haffner M, Lemaistre M, Schuler V, Kaeslin E, Korn R, Bürki K, Ledermann B, Kinzel B, Müller M.
Genesis. 2005 Aug;42(4):229-35

Knock-out animal for TAAR1 function
Hoener, Marius, Lindemann, Lothar, Meyer, Claas Aiko, Pauly-Evers, Meike, F. HOFFMANN-LA ROCHE AG
European Patent EP1760091A1

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