Rat Transgenesis

The rodent model of choice for physiological studies.

Beside the mouse model, rats are often chosen as the preferred animal model for the study of human diseases (or pathologies) in obesity, ageing, cancer, diabetes, transplantation, and cardiovascular research.

Rat models often show higher physiological similarities to humans than mice. Also, due to their larger size, surgical intervention can be performed and monitored more easily than in mice.
Up to now, genomic modification of the rat genome was mainly limited to the generation of transgenic rats via pronuclear injection of plasmid DNA or lentiviral particles.
Continuing these standard injection services, PolyGene and its Hungarian partner are now proud to further expand their collaboration and services to the development of knock-in rat and rabbit models.
The generation of targeted gene modifications in higher species than mice has become feasible due to the development of sequence specific DNA modifying nucleases, such as ZFNs, TALENS and CRISPR/Cas9.

Your advantage at PolyGene:

  • Applying sequence-specific genome engineering technologies allows PolyGene to offer highly reliable generation of knock out and knock-in rats on various backgrounds.
  • Genetically modified rats can be delivered in as little as 6 months.
  • Transgenic services are offered in Sprague Dawley and Lewis rats

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