PolyGene offers the complete range of gene targeting and transgenic model generation in mouse, rat and rabbit.
PolyGene is an innovative partner for large-scale scientific projects. We successfully collaborate within FP7 and always look for more.
Stay tuned for high-impact publications citing PolyGene mice, special offers, upcoming conferences and events.
Transgenic mice, rats and rabbits, from vector construction and tissue culture to injection of plasmids or ES cells plus breeding and delivery
Targeted modifications as knockouts, knock-ins and humanization using a variety of embryonic stem (ES) cell lines
Targeted modifications as knockouts and point mutations with nucleases including CRISPR/Cas9 and TALENs
A wide variety of accessory technologies, including scientific consultancy and technical support, mouse life insurances, sperm cryopreservation, etc.
Providing premium cell culture and genotyping products to guarantee continued success in your molecular research institute
The Swiss way! You expect quality, and you are entitled to it. We will have sleepless nights if anything doesn’t run smoothly, and we can’t be satisfied if you as a customer are not perfectly happy. Our business is tricky – we know that acting wisely, quickly, and decidedly is what we are called upon constantly, any day: with highest quality infrastructure and best-educated staff. And since we’re efficient, we can also beat low prices.
And of course, we know that just as much as good science, our business is also excellent communication and good relationships to scientists and colleagues.
A point mutation in a heart-relevant gene seems to be linked to arrhythmia – can we confirm this in a mouse model? Within a patient study, an overexpressed gene is found to be linked to cancer – does suppressing it prevent a mouse from getting cancer?
Well-designed mouse models give clear-cut explanations, validate targets in the pharma discovery process, or hypotheses in academic research, and deliver surprising and novel insights that would not be possible otherwise.
Generating them: this is profoundly ethical, deeply complex and interesting, greatly captivating, and fundamentally relevant.
We share your fervor and engagement and are proud to partake in your research!
8 years ago we made a knockout mouse unraveling the function of a calcium-binding protein (Calsequestrin) in the heart muscle. Finally it is published!
Several genetically modified mice models were studied so far to investigate the role of cardiac calsequestrin (CSQ2) for the contractile function of the ventricle and for the occurrence of ventricular tachycardia. By ...
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