A point mutation in a heart-relevant gene seems to be linked to arrhythmia – can we confirm this in a mouse model? Within a patient study, an overexpressed gene is found to be linked to cancer – does suppressing it prevent a mouse from getting cancer?

Well-designed mouse models give clear-cut explanations, validate targets in the pharma discovery process, or hypotheses in academic research, and deliver surprising and novel insights that would not be possible otherwise.

Generating them: this is profoundly ethical, deeply complex and interesting, greatly captivating, and fundamentally relevant.

We share your fervor and engagement and are proud to partake in your research!

The Swiss way! You expect quality, and you are entitled to it. We will have sleepless nights if anything doesn’t run smoothly, and we can’t be satisfied if you as a customer are not perfectly happy. Our business is tricky – we know that acting wisely, quickly, and decidedly is what we are called upon constantly, any day: with highest quality infrastructure and best-educated staff. And since we’re efficient, we can also beat low prices.

And of course, we know that just as much as good science, our business is also excellent communication and good relationships to scientists and colleagues.

• Novel humanized mouse model for heart disease research July 11, 2017 polygene

  Sudden cardiac death is caused by arrhythmias, which is defined as any deviation of the heart beat. Electrical heart disease leading to arrhythmias represents a major public health issue.

  The histidine-rich calcium-binding protein (HRC) Ser96Ala variant is known as potential biomarker for sudden cardiac death in patients with a heart muscle disease. HRC is a regulator ...

  » read more

• LRP4 mouse model helps to understand rare skeletal disease June 1, 2017 polygene

  Sclerosteosis is a rare autosomal recessive bone disorder marked by excessive bone growth of the skull and tubular bones. Up to now, research showed: sclerosteosis was caused by loss-of-function mutations in the SOST gene, encoding sclerostin.

  Recently, researchers within the european SYBIL consortium identified disease causing mutations in LRP4, a binding partner of sclerostin, ...

  » read more

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