Two distinct, antibiotic-driven (i.e. Erythromycin- or Pristinamycin-inducible) transgene expression systems are now available at PolyGene as both, DEREPRESSORS (EON & PON) and as DEACTIVATORS (EOFF & POFF).
In addition, we invite you to inquire about "AIR": our novel acetaldehyde-inducible transgenesis system
Major benefits:
A variety of configurations are there to be chosen from, to best suit your application.
Full patent coverage rights are easily available. System testing in mice revealed high fold-induction (i.e. dose-dependent and reversible).
Antibiotic-driven, inducible transgene expression systems
For a brief description of "modes of function" & "system positioning":
Inducibles 1&2 ... for further reading, we can recommend the following PubMed links (referenced articles):
PON & POFF: Fussenegger, M. et al., Nat. Biotechnol. 18, 1203-1208 (2000) EON & EOFF: Weber, W. et al., Nat. Biotechnol. 20, 901-906 (2002) Combinatorial control: Kramer, B. et al., Biotechnol. Bioeng. 87, 478-484 (2002) Dual regulation: Fux, C. et al., Nucleic Acids Res. 29, e19 (2001) Epigenetic switch: Kramer, B. et al., Nat. Biotechnol. 22, 867-870 (2004)Contact person: Stefan Selbert | Direct line: +41 (0)44 / 828 63 83
