The focus of the TumAdoR consortium is the development of human therapeutic monoclonal antibodies efficiently neutralizing a novel immunosuppressive pathway involved in a wide range of cancers. The project is based on studies that demonstrated a causative correlation of overexpression of CD73 with tumor proliferation and dissemination in numerous cancer types, by catalyzing high levels of extracellular Adenosine and thereby causing a immunosuppressive microenvironment. TumAdoR will extend the knowledge on this key pathway in cancer research. Neutralizing CD73 by developing clinically validated CD73 monoclonal antibodies represents a highly potent and innovative therapy.
PolyGene is generating a mouse model that uses an advanced and novel approach for the inducible humanization of CD73.