Transgenic Mouse and Rat Model Generation

Efficient transgenic services for mouse, rat and rabbit models.

A transgenic animal model describes a model which has been genetically modified through the use of genetic engineering techniques. For several animal models PolyGene offers efficient (non-) random integration of your transgene.

At PolyGene, designed plasmids or BACs are injected in the pronucleus of the oocyte and integrate randomly or non-randomly into the genome. The main advantage of this technique is the short development time – it takes about 2 months. Level and pattern of the transgene expression can vary due to unknown copy number and integration site, which makes it necessary to analyze several independent transgenic lines.
PolyGene gives guarantees for number of offspring and founders.

Pronuclear Microinjection is offered for the following animal model strains:

  • C57BL/6 mice
  • FVB mice
  • CB6F2 mice
  • Sprague Dawley rats
  • Lewis rats
  • Rabbits
Besides traditional cDNA-based, plasmid sized transgene microinjections PolyGene offers additional transgenic services:

BAC pronuclear microinjection
piggyBAC pronuclear microinjection

PolyGene offers the development of complete transgenic animal model projects, as well as partial services (e.g. scientific consulting, vector construction, pronuclear microinjection, genotyping).

Service Details on Transgenic Animal Generation GET A QUOTE

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