Animal Models

Advancing mammalian genetics and biotechnology.


At PolyGene, innovative as well as standard methods allow for the production of animals carrying foreign genes in a predefined manner: as tissue-specific genes, as single-copy or multi-copy cluster, as fusion genes, or in inducible or repressible form.

Gene Regulation

Gene Regulation

Hormone (mifepristone/ RU486) and antibiotic-driven (i.e. phloretin-, erythromycin- or pristinamycin-inducible) gene regulation systems for your inducible transgenic mouse model project are available at PolyGene. Major benefits: ...
Nuclease Systems<span class="new">new</span>

Nuclease Systemsnew

The field of genomic engineering is changing quickly during the last years. Beginning with custom zinc finger nucleases in 2009, a number of techniques have been established to facilitate the introduction of deletions and mutations into mammalian...
Rat Models <span class="new">new</span>

Rat Models new

Beside the mouse model, rats are often chosen as the preferred animal model for the study of human diseases (or pathologies) in obesity, ageing, cancer, diabetes, transplantation, and cardiovascular research. Rat models often show higher physiological...
Knockouts

Knockouts

Deleting a relevant mammalian gene constitutively (in the germ line) or conditionally (in certain tissues or upon intervention) is a way to investigate its malfunction or its potential as a drug target in a variety of disease areas – in neurodegeneration, c...
Knock-ins

Knock-ins

Gene knock-in can mean to generate a point mutation corresponding to a human morbid gene; or to use the genomic regulation and insert a coding frame – a fluorescent marker, a recombinase, or another foreign gene – instead of the previously present gen...
Overexpression

Overexpression

Innovative as well as standard methods allow for the production of animals carrying foreign genes in a predefined manner: as tissue-specific genes, as single-copy or multi-copy cluster, as fusion genes, or in inducible/ repressible form. PolyGene...
Speed Congenics

Speed Congenics

PolyGene offers a convenient way to test the genetic background of your valuable mouse line as an accurate strain quality control and for faster backcrossing. We apply a strain-specific tetranucleotide microsatellite-based screening to assure: GenoMouse™ i...
Cryopreservation

Cryopreservation

PolyGene offers an safe and cost-effective alternative to expensive breeding of your mouse strains. Choose between a standard or premium cryopreservation service.

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