Animal Models

Advancing mammalian genetics and biotechnology.


At PolyGene, innovative as well as standard methods allow for the production of animals carrying foreign genes in a predefined manner: as tissue-specific genes, as single-copy or multi-copy cluster, as fusion genes, or in inducible or repressible form.

Gene Regulation

Gene Regulation

Unique and powerful systems for inducible gene expression control.Hormone (mifepristone/ RU486) and antibiotic-driven (i.e. phloretin-, erythromycin- or pristinamycin-inducible) gene regulation systems for your inducible transgenic mouse model...
Nuclease Systems

Nuclease Systems

Nuclease based engineering at PolyGene. The field of genomic engineering is changing quickly during the last years. Beginning with custom zinc finger nucleases in 2009, a number of techniques have been established to facilitate the introduction of...
Rat Models

Rat Models

The rodent model of choice for physiological studies.Beside the mouse model, rats are often chosen as the preferred animal model for the study of human diseases (or pathologies) in obesity, ageing, cancer, diabetes, transplantation, and cardiovascular...
Tailor-made Knockout Mouse and Rat Models

Tailor-made Knockout Mouse and Rat Models

Turning off rodent genes to elucidate their function or model genetic diseases. Given the high similarity between rodent and human genomes, the laboratory mouse and rat are preferred model choices to understand biological mechanisms of genes and diseases...
Tailor-made Knock-in Mouse Models

Tailor-made Knock-in Mouse Models

Gene replacement by knock-in. Gene knock-in can mean to generate a point mutation corresponding to a human morbid gene; or to use the genomic regulation and insert a coding frame – a fluorescent marker, a recombinase, or another foreign gene – ins...
Overexpression

Overexpression

Transgenic animal model - workhorse of mammalian genetics. Innovative as well as standard methods allow for the production of animals carrying foreign genes in a predefined manner: as tissue-specific genes, as single-copy or multi-copy cluster, as...
Speed Congenics

Speed Congenics

Minimize your breeding efforts to generate a congenic strain.PolyGene offers a convenient way to test the genetic background of your valuable mouse line as an accurate strain quality control and for faster backcrossing. We apply a strain-specific...
Cryopreservation

Cryopreservation

The world's first life insurance for your valuable mouse strains. PolyGene freeze internal strains, both, to have safe back-up , and to be able to maintain a minimal size of holding colonies . We found that even for actively managed mouse strains,...

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